Conspectus Chain-walking offers extensive opportunities for innovating synthetic methods
that involve constructing chemical bonds at unconventional sites. This approach provides …

The direct difunctionalization of alkenes, a cheap and abundant feedstock, represents one of
the most attractive strategies for increasing molecular complexity in synthetic organic …

The merger of electrochemistry and transition metal catalysis has emerged as a powerful
tool to join two electrophiles in an enantioselective manner. However, the development of …

Chiral boronic esters are a class of versatile building blocks. We describe herein an
asymmetric nickel-catalyzed borylative coupling of terminal alkenes with nonactivated alkyl …

Substantial advances in enantioconvergent C (sp3)–C (sp3) bond formation reactions have
been made in recent years through the use of transition-metal-catalyzed cross-coupling …

Substituted six-membered cyclic hydrocarbons are common constituents of biologically
active compounds. Although methods for the synthesis of thermodynamically favored …

Migration of metals along a carbon chain is triggered by two of the most common
organometallic elementary steps–β-hydride (β-H) elimination and alkene hydrometallation …

Enantioselective difunctionalization of alkenes constitutes an efficient strategy to assemble
complex chiral molecules from simple racemic or achiral starting materials. Here we present …

Herein, we disclose a Ni-catalyzed 1, 1-difunctionalization of unactivated terminal alkenes
that enables the incorporation of two different heteroatom motifs across an olefin backbone …

The design of a single complicated chiral ligand to well-promote each step of an asymmetric
cascade reaction is sometimes a formidable challenge in transition metal catalysis. In this …