Emerging roles and functional mechanisms of PIWI-interacting RNAs
X Wang, A Ramat, M Simonelig, MF Liu - Nature Reviews Molecular …, 2023 - nature.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
RNA granules: functional compartments or incidental condensates?
RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …
Germ granule compartments coordinate specialized small RNA production
X Chen, K Wang, FUD Mufti, D Xu, C Zhu… - Nature …, 2024 - nature.com
Germ granules are biomolecular condensates present in most animal germ cells. One
function of germ granules is to help maintain germ cell totipotency by organizing mRNA …
function of germ granules is to help maintain germ cell totipotency by organizing mRNA …
HERD-1 mediates multiphase condensate immiscibility to regulate small RNA-driven transgenerational epigenetic inheritance
C Zhao, S Cai, R Shi, X Li, B Deng, R Li, S Yang… - Nature Cell …, 2024 - nature.com
Biomolecular condensates, such as the nucleolus, stress granules/processing bodies and
germ granules, are multiphase assemblages whose formation mechanisms and significance …
germ granules, are multiphase assemblages whose formation mechanisms and significance …
Connecting the dots: linking Caenorhabditis elegans small RNA pathways and germ granules
Germ granules are non-membrane bound, phase-separated organelles, composed of RNAs
and proteins. Germ granules are present only within the germ cells of animals, including …
and proteins. Germ granules are present only within the germ cells of animals, including …
Germ granules and gene regulation in the Caenorhabditis elegans germline
CM Phillips, DL Updike - Genetics, 2022 - academic.oup.com
The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …
C. elegans germ granules sculpt both germline and somatic RNAome
IF Price, JA Wagner, B Pastore, HL Hertz… - Nature …, 2023 - nature.com
Germ granules are membrane-less organelles essential for small RNA biogenesis and
germline development. Among the conserved properties of germ granules is their …
germline development. Among the conserved properties of germ granules is their …
RG/RGG repeats in the C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation
EL Spaulding, AM Feidler, LA Cook… - Nature …, 2022 - nature.com
The intrinsically disordered RG/RGG repeat domain is found in several nucleolar and P-
granule proteins, but how it influences their phase separation into biomolecular …
granule proteins, but how it influences their phase separation into biomolecular …
Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans
It is unknown whether transient transgenerational epigenetic responses to environmental
challenges affect the process of evolution, which typically unfolds over many generations …
challenges affect the process of evolution, which typically unfolds over many generations …
[HTML][HTML] It's just a phase: exploring the relationship between mRNA, biomolecular condensates, and translational control
DM Parker, LP Winkenbach… - Frontiers in …, 2022 - frontiersin.org
Cells spatially organize their molecular components to carry out fundamental biological
processes and guide proper development. The spatial organization of RNA within the cell …
processes and guide proper development. The spatial organization of RNA within the cell …