Emerging roles and functional mechanisms of PIWI-interacting RNAs

X Wang, A Ramat, M Simonelig, MF Liu - Nature Reviews Molecular …, 2023 - nature.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

RNA granules: functional compartments or incidental condensates?

A Putnam, L Thomas, G Seydoux - Genes & development, 2023 - genesdev.cshlp.org
RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …

Germ granule compartments coordinate specialized small RNA production

X Chen, K Wang, FUD Mufti, D Xu, C Zhu… - Nature …, 2024 - nature.com
Germ granules are biomolecular condensates present in most animal germ cells. One
function of germ granules is to help maintain germ cell totipotency by organizing mRNA …

HERD-1 mediates multiphase condensate immiscibility to regulate small RNA-driven transgenerational epigenetic inheritance

C Zhao, S Cai, R Shi, X Li, B Deng, R Li, S Yang… - Nature Cell …, 2024 - nature.com
Biomolecular condensates, such as the nucleolus, stress granules/processing bodies and
germ granules, are multiphase assemblages whose formation mechanisms and significance …

Connecting the dots: linking Caenorhabditis elegans small RNA pathways and germ granules

AE Sundby, RI Molnar, JM Claycomb - Trends in Cell Biology, 2021 - cell.com
Germ granules are non-membrane bound, phase-separated organelles, composed of RNAs
and proteins. Germ granules are present only within the germ cells of animals, including …

Germ granules and gene regulation in the Caenorhabditis elegans germline

CM Phillips, DL Updike - Genetics, 2022 - academic.oup.com
The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …

C. elegans germ granules sculpt both germline and somatic RNAome

IF Price, JA Wagner, B Pastore, HL Hertz… - Nature …, 2023 - nature.com
Germ granules are membrane-less organelles essential for small RNA biogenesis and
germline development. Among the conserved properties of germ granules is their …

RG/RGG repeats in the C. elegans homologs of Nucleolin and GAR1 contribute to sub-nucleolar phase separation

EL Spaulding, AM Feidler, LA Cook… - Nature …, 2022 - nature.com
The intrinsically disordered RG/RGG repeat domain is found in several nucleolar and P-
granule proteins, but how it influences their phase separation into biomolecular …

Transgenerational inheritance of sexual attractiveness via small RNAs enhances evolvability in C. elegans

IA Toker, I Lev, Y Mor, Y Gurevich, D Fisher… - Developmental Cell, 2022 - cell.com
It is unknown whether transient transgenerational epigenetic responses to environmental
challenges affect the process of evolution, which typically unfolds over many generations …

[HTML][HTML] It's just a phase: exploring the relationship between mRNA, biomolecular condensates, and translational control

DM Parker, LP Winkenbach… - Frontiers in …, 2022 - frontiersin.org
Cells spatially organize their molecular components to carry out fundamental biological
processes and guide proper development. The spatial organization of RNA within the cell …