The process of poly (ADP-ribosyl) ation and the major enzyme that catalyses this reaction,
poly (ADP-ribose) polymerase 1 (PARP1), were discovered more than 50 years ago. Since …

Stroke is one of the leading causes of morbidity and mortality accompanied by blood supply
loss to a particular brain area. Several mechanistic approaches such as inhibition of poly …

Therapy resistance has long been considered to occur through the selection of pre-existing
clones equipped to survive and quickly regrow, or through the acquisition of mutations …

Sepsis is a dysregulated response to infection that can result in life-threatening organ
failure, and septic cardiomyopathy is a serious complication involving ferroptosis. Olaparib …

3-mercaptopyruvate sulfurtransferase (3-MST) has emerged as one of the significant
sources of biologically active sulfur species in various mammalian cells. The current study …

Sepsis is a syndrome characterized by life-threatening organ dysfunction caused by the
dysregulated host response to an infection. Sepsis, especially septic shock and multiple …

Sepsis is not only a threat to the health of individual patients but also presents a serious
epidemiological problem. Despite intensive research, modern sepsis therapy remains based …

PARP1, the major isoform of a family of ADP-ribosylating enzymes, has been implicated in
the regulation of various biological processes including DNA repair, gene transcription, and …

Poly (ADP-ribose) polymerase 1 (PARP1), as a potential target for the experimental therapy
of acute lung injury (ALI), was identified over 20 years ago. However, clinical translation of …

Highlights•Understanding different pathways leading to PARP activation.•Role of PARP in
the pathogenesis of lung, heart, liver and kidney fibrosis.•PARP inhibitors as a possible …