Owing to advances in radiotherapy, the physical properties of radiation can be optimized to
enable individualized treatment; however, optimization is rarely based on biological …

Radiation oncology exploits the biological interaction of radiation within tissue to promote
tumor death while minimizing damage to surrounding normal tissue. The clinical delivery of …

Background & Aims Copper (Cu) is an essential trace element whose serum levels have
been reported to act as an effective indicator of the efficacy of radiotherapy. However, little is …

Background Despite advances in cancer genomics, radiotherapy is still prescribed on the
basis of an empirical one-size-fits-all paradigm. Previously, we proposed a novel algorithm …

Background Despite its common use in cancer treatment, radiotherapy has not yet entered
the era of precision medicine, and there have been no approaches to adjust dose based on …

Purpose: Previously, we developed a radiosensitivity molecular signature [radiosensitivity
index (RSI)] that was clinically validated in 3 independent datasets (rectal, esophageal, and …

Purpose/Objectives Evidence from the management of oligometastases with stereotactic
body radiation therapy (SBRT) reveals differences in outcomes based on primary histology …

A paradigm shift from current population based medicine to personalized and participative
medicine is underway. This transition is being supported by the development of clinical …

Radiotherapy is a primary therapeutic modality widely utilized with curative intent.
Traditionally tumor response was hypothesized to be due to high levels of cell death …

We have previously developed a multigene expression model of tumor radiosensitivity (RSI)
with clinical validation in multiple cohorts and disease sites. We hypothesized RSI would …