One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Tubulin proteins, as components of the microtubule cytoskeleton perform critical cellular
functions throughout all phases of the cell cycle. Altered tubulin isotype composition of …

Microtubule proteins form a dynamic component of the cytoskeleton, and play key roles in
cellular processes, such as vesicular transport, cell motility and mitosis. Expression of …

Microtubules (MTs), highly dynamic structures composed of α-and β-tubulin heterodimers,
are involved in cell movement and intracellular traffic and are essential for cell division …

Class III β-tubulin (βIII-tubulin) is frequently overexpressed in human tumors and is
associated with resistance to microtubule-targeting agents, tumor aggressiveness, and poor …

MicroRNAs are critical mediators of stem cell pluripotency, differentiation, and malignancy.
Limited information exists regarding microRNA alterations that facilitate initiation and …

Inactivation of the tumor suppressor gene RASSF1A by promoter hypermethylation
represents a key event underlying the initiation and progression of lung cancer. RASSF1A …

Lung cancer is the leading cause of cancer mortality worldwide in both men and women.
Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for …

Microtubules are polymeric structures composed of tubulin subunits. Each subunit consists
of a heterodimer of α-and β-tubulin. At least seven β-tubulin isotypes, or classes, have been …