Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

[HTML][HTML] Cellular senescence in lung cancer: Molecular mechanisms and therapeutic interventions

SK Jha, G De Rubis, SR Devkota, Y Zhang… - Ageing Research …, 2024 - Elsevier
Lung cancer stands as the primary contributor to cancer-related fatalities worldwide,
affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC) …

18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration

KR Paudel, MSB Mohamad, G De Rubis… - Journal of Drug Delivery …, 2024 - Elsevier
Conventional treatment methods to treat lung cancer include radiation therapy,
chemotherapy, and immunotherapy. However, they cause severe adverse effects and …

Docetaxel-loaded nanoformulations delivery for breast cancer management: Challenges, recent advances, and future perspectives

VK Panthi, S Bashyal, KR Paudel - Journal of Drug Delivery Science and …, 2023 - Elsevier
Breast cancer (BC) is a major health and financial hardship globally, and conventional
chemotherapy has bounded success in thoroughly treating the disease. It can result in …

[HTML][HTML] The nexus of inflammation-induced epithelial-mesenchymal transition and lung cancer progression: a roadmap to pentacyclic triterpenoid-based therapies

KV Odarenko, MA Zenkova, AV Markov - International Journal of …, 2023 - mdpi.com
Lung cancer is the leading cause of cancer-related death worldwide. Its high mortality is
partly due to chronic inflammation that accompanies the disease and stimulates cancer …

[HTML][HTML] Anti-inflammatory and anti-fibrotic effects of berberine-loaded liquid crystalline nanoparticles

A Chakraborty, KR Paudel, C Wang, G De Rubis… - EXCLI …, 2023 - ncbi.nlm.nih.gov
Inflammation is a common protective response activated within several tissues and organs
upon exposure to potentially damaging or threatening stimuli. When the inflammatory …

[HTML][HTML] Wnt/β-catenin signaling in the development and therapeutic resistance of non-small cell lung cancer

Z Zhang, D Westover, Z Tang, Y Liu, J Sun… - Journal of Translational …, 2024 - Springer
Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic
response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators …

The development of nanocarriers for natural products

L Huang, S Luo, S Tong, Z Lv… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Natural bioactive compounds from plants exhibit substantial pharmacological potency and
therapeutic value. However, the development of most plant bioactive compounds is …

Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges

S Kokkinis, M Singh, KR Paudel, G De Rubis, AB Saeid… - Food Bioscience, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a widespread global health problem
marked by increasing airflow limitation and chronic airway inflammation. Conventional …

[HTML][HTML] Integrating Chinese medicine into mainstream cancer therapies: a promising future

B Ni, K Xue, J Wang, J Zhou, L Wang, X Wang… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Malignant tumors are complex systemic chronic diseases and one of the major causes of
human mortality. Targeted therapy, chemotherapy, immunotherapy, and radiotherapy are …