Short chain fatty acids: microbial metabolites for gut-brain axis signalling

KJ O'Riordan, MK Collins, GM Moloney… - Molecular and Cellular …, 2022 - Elsevier
The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to
prominence in recent years. Understanding the relationship between the gut microbiota, the …

[HTML][HTML] Brain–gut–microbiota axis in depression: A historical overview and future directions

L Chang, Y Wei, K Hashimoto - Brain Research Bulletin, 2022 - Elsevier
Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

BD Needham, M Funabashi, MD Adame, Z Wang… - Nature, 2022 - nature.com
Integration of sensory and molecular inputs from the environment shapes animal behaviour.
A major site of exposure to environmental molecules is the gastrointestinal tract, in which …

The maternal microbiome modulates fetal neurodevelopment in mice

HE Vuong, GN Pronovost, DW Williams, EJL Coley… - Nature, 2020 - nature.com
Abstract 'Dysbiosis' of the maternal gut microbiome, in response to challenges such as
infection, altered diet and stress during pregnancy, has been increasingly associated with …

The microbiota-gut-brain axis

JF Cryan, KJ O'Riordan, CSM Cowan… - Physiological …, 2019 - journals.physiology.org
I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders

J Horn, DE Mayer, S Chen, EA Mayer - Translational psychiatry, 2022 - nature.com
There is emerging evidence that diet has a major modulatory influence on brain-gut-
microbiome (BGM) interactions with important implications for brain health, and for several …

[HTML][HTML] Mechanisms of action of probiotics

J Plaza-Diaz, FJ Ruiz-Ojeda, M Gil-Campos, A Gil - Advances in nutrition, 2019 - Elsevier
Probiotics are living microorganisms that confer health benefits to the host when
administered in adequate amounts; however, dead bacteria and their components can also …

Gut microbial molecules in behavioural and neurodegenerative conditions

BD Needham, R Kaddurah-Daouk… - Nature Reviews …, 2020 - nature.com
Mounting evidence suggests that the gut microbiome impacts brain development and
function. Gut–brain connections may be mediated by an assortment of microbial molecules …

[HTML][HTML] Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder

M Sgritta, SW Dooling, SA Buffington, EN Momin… - Neuron, 2019 - cell.com
Currently, there are no medications that effectively treat the core symptoms of Autism
Spectrum Disorder (ASD). We recently found that the bacterial species Lactobacillus (L.) …

Role of gut microbiome in autism spectrum disorder and its therapeutic regulation

MA Taniya, HJ Chung, A Al Mamun, S Alam… - Frontiers in cellular …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a neurological disorder that affects normal brain
development. The recent finding of the microbiota–gut–brain axis indicates the bidirectional …