The role of short-chain fatty acids in microbiota–gut–brain communication

B Dalile, L Van Oudenhove, B Vervliet… - Nature reviews …, 2019 - nature.com
Short-chain fatty acids (SCFAs), the main metabolites produced by bacterial fermentation of
dietary fibre in the gastrointestinal tract, are speculated to have a key role in microbiota–gut …

[HTML][HTML] Whole fruits and fruit fiber emerging health effects

ML Dreher - Nutrients, 2018 - mdpi.com
Less than 10% of most Western populations consume adequate levels of whole fruits and
dietary fiber with typical intake being about half of the recommended levels. Evidence of the …

Short-chain fatty acid receptors and cardiovascular function

A Lymperopoulos, MS Suster, JI Borges - International Journal of …, 2022 - mdpi.com
Increasing experimental and clinical evidence points toward a very important role for the gut
microbiome and its associated metabolism in human health and disease, including in …

Short-chain fatty acid, acylation and cardiovascular diseases

XF Chen, X Chen, X Tang - Clinical Science, 2020 - portlandpress.com
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide.
Metabolic dysfunction is a fundamental core mechanism underlying CVDs. Previous studies …

Microbiome—microbial metabolome—cancer cell interactions in breast cancer—familiar, but unexplored

E Mikó, T Kovács, É Sebő, J Tóth, T Csonka, G Ujlaki… - Cells, 2019 - mdpi.com
Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant
composition of the microbiome, characterizes breast cancer. In this review we discuss the …

The role of short-chain fatty acids of gut microbiota origin in hypertension

Y Wu, H Xu, X Tu, Z Gao - Frontiers in Microbiology, 2021 - frontiersin.org
Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases,
and its development involves multiple mechanisms. Gut microbiota has been reported to be …

Free fatty acid receptors (FFARs) in adipose: physiological role and therapeutic outlook

S Al Mahri, SS Malik, M Al Ibrahim, E Haji, G Dairi… - Cells, 2022 - mdpi.com
Fatty acids (FFAs) are important biological molecules that serve as a major energy source
and are key components of biological membranes. In addition, FFAs play important roles in …

Modulation of short‐chain fatty acids as potential therapy method for type 2 diabetes mellitus

R Tang, L Li - Canadian Journal of Infectious Diseases and …, 2021 - Wiley Online Library
In recent years, the relationship between intestinal microbiota (IM) and the pathogenesis of
type 2 diabetes mellitus (T2DM) has attracted much attention. The beneficial effects of IM on …

Free fatty acid receptors 2 and 3 as microbial metabolite sensors to shape host health: pharmacophysiological view

SP Mishra, P Karunakar, S Taraphder, H Yadav - Biomedicines, 2020 - mdpi.com
The role of the gut microbiome in human health is becoming apparent. The major functional
impact of the gut microbiome is transmitted through the microbial metabolites that are …

The microbiome as a component of the tumor microenvironment

T Kovács, E Mikó, G Ujlaki, Z Sári, P Bai - Tumor Microenvironment …, 2020 - Springer
Microbes, which live in the human body, affect a large set of pathophysiological processes.
Changes in the composition and proportion of the microbiome are associated with metabolic …