Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

The activated product of the myc oncogene deregulates both cell growth and death check
points and, in a permissive environment, rapidly accelerates the affected clone through the …

Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course
ranges from spontaneous tumor regression to fatal progression. To investigate the molecular …

Telomerase is elevated in> 90% of breast carcinomas and therefore has received much
attention as a target for breast cancer therapy and cancer diagnostic research. Dietary …

Neuroblastoma remains a significant challenge as high-risk patients are treated with
intensive multimodal therapies but cure rates remain suboptimal. There is remarkable …

Purpose Maintenance of telomeres through reactivation of telomerase is a prerequisite for
tumors to preserve their ability to proliferate. The purpose of this study was to evaluate …

Telomere maintenance is regarded as a key mechanism in overcoming cellular senescence
in tumor cells and in most cases is achieved by the activation of telomerase. However there …

Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, is
very closely associated with telomerase activity. Telomerase has been implicated in cellular …

Telomerase activity (TA) has been shown to correlate with poor clinical outcome in various
tumour entities, indicating that tumours expressing this enzyme may be more aggressive …

PURPOSE Telomere maintenance is a hallmark of high-risk neuroblastoma; however, the
contribution of telomerase and alternative lengthening of telomeres (ALT) to clinical …