Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions

D Tesei, A Jewczynko, AM Lynch, C Urbaniak - Life, 2022 - mdpi.com
During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …

Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight

J Park, EG Overbey, SA Narayanan, JK Kim… - Nature …, 2024 - nature.com
Spaceflight can change metabolic, immunological, and biological homeostasis and cause
skin rashes and irritation, yet the molecular basis remains unclear. To investigate the impact …

Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight

BT Tierney, JK Kim, EG Overbey, KA Ryon, J Foox… - Nature …, 2024 - nature.com
Maintenance of astronaut health during spaceflight will require monitoring and potentially
modulating their microbiomes. However, documenting microbial shifts during spaceflight has …

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

EG Overbey, K Ryon, JK Kim, BT Tierney… - Nature …, 2024 - nature.com
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …

Multidrug-resistant Acinetobacter pittii is adapting to and exhibiting potential succession aboard the International Space Station

BT Tierney, NK Singh, AC Simpson, AM Hujer… - Microbiome, 2022 - Springer
Background Monitoring the adaptation of microorganisms to the extreme environment of the
International Space Station (ISS) is crucial to understanding microbial evolution and …

[HTML][HTML] Migration of surface-associated microbial communities in spaceflight habitats

D Marra, T Karapantsios, S Caserta, E Secchi… - Biofilm, 2023 - Elsevier
Astronauts are spending longer periods locked up in ships or stations for scientific and
exploration spatial missions. The International Space Station (ISS) has been inhabited …

Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome

P Madrigal, NK Singh, JM Wood, E Gaudioso… - Microbiome, 2022 - Springer
Background Antimicrobial resistance (AMR) has a detrimental impact on human health on
Earth and it is equally concerning in other environments such as space habitat due to …

Physiological alterations in relation to space flight: the role of nutrition

S Chaloulakou, KA Poulia, D Karayiannis - Nutrients, 2022 - mdpi.com
Astronauts exhibit several pathophysiological changes due to a variety of stressors related
to the space environment, including microgravity, space radiation, isolation, and …

Effect of microgravity environment on gut microbiome and angiogenesis

R Siddiqui, R Qaisar, N Goswami, NA Khan… - Life, 2021 - mdpi.com
Microgravity environments are known to cause a plethora of stressors to astronauts.
Recently, it has become apparent that gut microbiome composition of astronauts is altered …