The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics

SA Kent, TL Spires-Jones, CS Durrant - Acta neuropathologica, 2020 - Springer
Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

Talimogene laherparepvec (T-VEC) and other oncolytic viruses for the treatment of melanoma

PK Bommareddy, A Patel, S Hossain… - American journal of …, 2017 - Springer
Many mammalian viruses have properties that can be commandeered for the treatment of
cancer. These characteristics include preferential infection and replication in tumor cells, the …

[HTML][HTML] Trial of beremagene geperpavec (B-VEC) for dystrophic epidermolysis bullosa

SV Guide, ME Gonzalez, IS Bağcı… - … England Journal of …, 2022 - Mass Medical Soc
Background Dystrophic epidermolysis bullosa is a rare genetic blistering skin disease
caused by mutations in COL7A1, which encodes type VII collagen (C7). Beremagene …

Viral infections

JC Sterling - Rook's Textbook of Dermatology, Ninth Edition, 2016 - Wiley Online Library
Skin disease due to viruses may be a primary infection of the epidermis or may arise
secondary to systemic infection. Depending on the virus, the effects may be necrotic damage …

Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review

JS Smith, NJ Robinson - The Journal of infectious diseases, 2002 - academic.oup.com
Abstract Information on age-and sex-specific prevalence of herpes simplex virus (HSV)
types 2 and 1 infections is essential to optimize genital herpes control strategies, which …

Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States

F Xu, MR Sternberg, BJ Kottiri, GM McQuillan, FK Lee… - Jama, 2006 - jamanetwork.com
ContextHerpes simplex virus type 1 (HSV-1) and type 2 are common infections worldwide.
Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes and is almost …

Human herpes simplex virus infections: epidemiology, pathogenesis, symptomatology, diagnosis, and management

M Fatahzadeh, RA Schwartz - Journal of the American Academy of …, 2007 - Elsevier
Eight of the more than 80 known herpesviruses are human pathogens. Human herpes
simplex virus (HSV) is a contagious infection with a large reservoir in the general population …

Herpes simplex viruses

RJ Whitley, DW Kimberlin, B Roizman - Clinical Infectious Diseases, 1998 - JSTOR
Herpes simplex virus (HSV) infections of humans were first documented in ancient Greece.
Greek scholars, particularly Hippocrates, used the word" herpes," meaning to creep or crawl …

The molecular basis of herpes simplex virus latency

MP Nicoll, JT Proença… - FEMS microbiology …, 2012 - academic.oup.com
Herpes simplex virus type 1 is a neurotropic herpesvirus that establishes latency within
sensory neurones. Following primary infection, the virus replicates productively within …

Herpes Simplex Virus Type 1 infection: overview on relevant clinico‐pathological features

PG Arduino, SR Porter - Journal of oral pathology & medicine, 2008 - Wiley Online Library
Herpes Simplex Virus Type 1 (HSV‐1) is a nuclear replicating enveloped virus, usually
acquired through direct contact with infected lesions or body fluids (typically saliva). The …