Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

We present an in silico approach to identifying neoepitopes derived from intron retention
events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we …

The nucleus is highly compartmentalized through the formation of distinct classes of
membraneless domains. However, the composition and function of many of these structures …

A number of long noncoding RNA s (lnc RNA s) are induced in response to specific stresses
to construct membrane‐less nuclear bodies; however, their function remains poorly …

Homeothermic organisms maintain their core body temperature in a narrow, tightly
controlled range. Whether and how subtle circadian oscillations or disease-associated …

Background Both aberrant alternative splicing and m6A methylation play complicated roles
in the development of pancreatic cancer (PC), while the relationship between these two …

High-throughput RNA sequencing (RNA-seq) has revealed an enormous complexity of
alternative splicing (AS) across diverse cell and tissue types. However, it is currently …

Abstract CDK12 (cyclin-dependent kinase 12) is a regulatory kinase with evolutionarily
conserved roles in modulating transcription elongation. Recent tumor genome studies of …

Nuclear stress bodies (nSBs) are nuclear membraneless organelles formed around stress‐
inducible HSATIII architectural long noncoding RNAs (lncRNAs). nSBs repress splicing of …