Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use
Genetic decoding is not 'frozen'as was earlier thought, but dynamic. One facet of this is
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …
Ebolavirus Glycoprotein Structure and Mechanism of Entry
JE Lee, EO Saphire - Future virology, 2009 - Taylor & Francis
Ebolavirus (EBOV) is a highly virulent pathogen capable of causing a severe hemorrhagic
fever with 50–90% lethality. The EBOV glycoprotein (GP) is the only virally expressed …
fever with 50–90% lethality. The EBOV glycoprotein (GP) is the only virally expressed …
Shed GP of Ebola virus triggers immune activation and increased vascular permeability
B Escudero-Pérez, VA Volchkova, O Dolnik… - PLoS …, 2014 - journals.plos.org
During Ebola virus (EBOV) infection a significant amount of surface glycoprotein GP is shed
from infected cells in a soluble form due to cleavage by cellular metalloprotease TACE …
from infected cells in a soluble form due to cleavage by cellular metalloprotease TACE …
Molecular determinants of Ebola virus virulence in mice
H Ebihara, A Takada, D Kobasa, S Jones… - PLoS …, 2006 - journals.plos.org
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman
primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme …
primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme …
Filovirus replication and transcription
E Mühlberger - Future virology, 2007 - Taylor & Francis
The highly pathogenic filoviruses, Marburg and Ebola virus, belong to the nonsegmented
negative-sense RNA viruses of the order Mononegavirales. The mode of replication and …
negative-sense RNA viruses of the order Mononegavirales. The mode of replication and …
The multiple roles of sGP in Ebola pathogenesis
MA de La Vega, G Wong, GP Kobinger, X Qiu - Viral immunology, 2015 - liebertpub.com
Ebola causes severe hemorrhagic fever in humans and nonhuman primates, and there are
currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) …
currently no approved therapeutic countermeasures. The virulence of Ebola virus (EBOV) …
Steric shielding of surface epitopes and impaired immune recognition induced by the ebola virus glycoprotein
JR Francica, A Varela-Rohena, A Medvec… - PLoS …, 2010 - journals.plos.org
Many viruses alter expression of proteins on the surface of infected cells including
molecules important for immune recognition, such as the major histocompatibility complex …
molecules important for immune recognition, such as the major histocompatibility complex …
Characterization of Zaire ebolavirus glycoprotein-specific monoclonal antibodies
Zaire ebolavirus (ZEBOV) can be transmitted by human-to-human contact and causes acute
haemorrhagic fever with case fatality rates up to 90%. There are no effective therapeutic or …
haemorrhagic fever with case fatality rates up to 90%. There are no effective therapeutic or …
Immunopathology of highly virulent pathogens: insights from Ebola virus
CA Zampieri, NJ Sullivan, GJ Nabel - Nature immunology, 2007 - nature.com
Ebola virus is a highly virulent pathogen capable of inducing a frequently lethal hemorrhagic
fever syndrome. Accumulating evidence indicates that the virus actively subverts both innate …
fever syndrome. Accumulating evidence indicates that the virus actively subverts both innate …
Intracellular events and cell fate in filovirus infection
J Olejnik, E Ryabchikova, RB Corley, E Mühlberger - Viruses, 2011 - mdpi.com
Marburg and Ebola viruses cause a severe hemorrhagic disease in humans with high
fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic …
fatality rates. Early target cells of filoviruses are monocytes, macrophages, and dendritic …