Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …
[HTML][HTML] Advances in our understanding of oxylipins derived from dietary PUFAs
M Gabbs, S Leng, JG Devassy, M Monirujjaman… - Advances in …, 2015 - Elsevier
Oxylipins formed from polyunsaturated fatty acids (PUFAs) are the main mediators of PUFA
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …
effects in the body. They are formed via cyclooxygenase, lipoxygenase, and cytochrome …
[HTML][HTML] A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation
HH Yang, JX Duan, SK Liu, JB Xiong, XX Guan… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Dysregulation of arachidonic acid (ARA) metabolism results in inflammation;
however, its role in acute lung injury (ALI) remains elusive. In this study, we addressed the …
however, its role in acute lung injury (ALI) remains elusive. In this study, we addressed the …
Pharmacogenomics of CYP2C9: Functional and Clinical Considerations†
CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
important contributor from this subfamily to drug metabolism. Polymorphisms resulting in …
Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases
WH Schunck, A Konkel, R Fischer… - Pharmacology & …, 2018 - Elsevier
Numerous benefits have been attributed to dietary long-chain omega-3 polyunsaturated fatty
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …
acids (n-3 LC-PUFAs), including protection against cardiac arrhythmia, triglyceride-lowering …
Role of cytochrome P450 2C8 in drug metabolism and interactions
Abstract During the last 10-15 years, cytochrome P450 (CYP) 2C8 has emerged as an
important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is …
important drug-metabolizing enzyme. CYP2C8 is highly expressed in human liver and is …
Role of oxylipins in cardiovascular diseases
MA Nayeem - Acta Pharmacologica Sinica, 2018 - nature.com
Globally, cardiovascular diseases (CVDs) are the number one cause of mortality.
Approximately 18 million people died from CVDs in 2015, representing more than 30% of all …
Approximately 18 million people died from CVDs in 2015, representing more than 30% of all …
CYP450 epoxygenase metabolites, epoxyeicosatrienoic acids, as novel anti-inflammatory mediators
Z Shi, Z He, DW Wang - Molecules, 2022 - mdpi.com
Inflammation plays a crucial role in the initiation and development of a wide range of
systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) …
systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) …
20-HETE in the regulation of vascular and cardiac function
P Rocic, ML Schwartzman - Pharmacology & therapeutics, 2018 - Elsevier
HETE, the ω-hydroxylation product of arachidonic acid catalyzed by enzymes of the
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …
Dietary modulation of oxylipins in cardiovascular disease and aging
SPB Caligiuri, M Parikh… - American Journal …, 2017 - journals.physiology.org
Oxylipins are a group of fatty acid metabolites generated via oxygenation of polyunsaturated
fatty acids and are involved in processes such as inflammation, immunity, pain, vascular …
fatty acids and are involved in processes such as inflammation, immunity, pain, vascular …