Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

The importance of Zn for human health becomes obvious during Zn deficiency. Even mild
insufficiencies of Zn cause alterations in haematopoiesis and immune functions, resulting in …

Redox signalling in mitochondria plays an important role in myocardial
ischaemia/reperfusion (I/R) injury and in cardioprotection. Reactive oxygen and nitrogen …

Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to
shrink tumors. Crucial for apoptotic function are executioner caspases, most notably …

Oxidative stress and insulin resistance are two key mechanisms for the development of
diabetic cardiomyopathy (DCM, cardiac remodeling and dysfunction). In this review, we …

Zinc plays an important role in cardiomyocytes, where it exists in bound and histochemically
reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through …

Zinc is structurally and functionally essential for more than 300 enzymes and 2000
transcription factors in human body. Intracellular labile zinc is the metabolically effective zinc …

The presence of Zn 2+ at protein–protein interfaces modulates complex function, stability,
and introduces structural flexibility/complexity, chemical selectivity, and reversibility driven in …

The zinc oxide nanoparticles (ZnO-NPs) being widely employed in several industries and
consumer products, are raising concerns about their safety on aquatic biota and human …

Zinc plays a critical role in many physiological processes, and disruption of zinc
homeostasis induces various disorders, such as growth retardation, osteopenia, immune …