Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …

Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …

Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …

Abstract Beckman, Kenneth B., and Bruce N. Ames. The Free Radical Theory of Aging
Matures. Physiol. Rev. 78: 547–581, 1998.—The free radical theory of aging, conceived in …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …

Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial
respiratory electron transport chain, which utilize a unique heterobinuclear active site to …

Research in the field of molecular biology has helped to provide a better understanding of
both the cascade of biochemical events that occurs with Alzheimer disease (AD) and the …

Defects of mitochondrial metabolism cause a wide range of human diseases that include
examples from all medical subspecialties. This review updates the topic of mitochondrial …

Alzheimer's disease (AD) includes etiologically heterogenous disorders characterized by
senile or presenile dementia, extracellular amyloid protein aggregations containing an …

Oxidative balance is emerging as an important issue in understanding the pathogenesis of
Alzheimer's disease. Examination of Alzheimer's disease brain has demonstrated a great …