ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease

DSA Simpson, PL Oliver - Antioxidants, 2020 - mdpi.com
Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

Lutein and zeaxanthin and their roles in age-related macular degeneration—neurodegenerative disease

M Mrowicka, J Mrowicki, E Kucharska, I Majsterek - Nutrients, 2022 - mdpi.com
Lutein and zeaxanthin belong to the xanthophyll family of carotenoids, which are pigments
produced by plants. Structurally, they are very similar, differing only slightly in the …

Antioxidant-rich natural fruit and vegetable products and human health

AIO Jideani, H Silungwe, T Takalani… - … Journal of Food …, 2021 - Taylor & Francis
Antioxidants are important ingredients that are present in fruits and vegetables (FAV). With
increased consumption of FAV in its raw and processed form, a predominantly plant-based …

NF-κB in oxidative stress

K Lingappan - Current opinion in toxicology, 2018 - Elsevier
The transcription factor nuclear factor-κB (NF-κB) modulates gene expression in diverse
cellular processes such as innate immune response, embryogenesis and organ …

ROS and ROS‐mediated cellular signaling

J Zhang, X Wang, V Vikash, Q Ye, D Wu… - Oxidative medicine …, 2016 - Wiley Online Library
It has long been recognized that an increase of reactive oxygen species (ROS) can modify
the cell‐signaling proteins and have functional consequences, which successively mediate …

Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis

AR Phull, B Nasir, I ul Haq, SJ Kim - Chemico-biological interactions, 2018 - Elsevier
There are numerous extra-and intra-cellular processes involved in the production of reactive
oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules …

[HTML][HTML] Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

MT Kabir, MH Rahman, M Shah, MR Jamiruddin… - Biomedicine & …, 2022 - Elsevier
Abstract Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …

Mitochondrial ROS govern the LPS-induced pro-inflammatory response in microglia cells by regulating MAPK and NF-κB pathways

J Park, JS Min, B Kim, UB Chae, JW Yun, MS Choi… - Neuroscience …, 2015 - Elsevier
Activation of microglia cells in the brain contributes to neurodegenerative processes
promoted by many neurotoxic factors such as pro-inflammatory cytokines and nitric oxide …

Role of endogenous lipopolysaccharides in neurological disorders

M Kalyan, AH Tousif, S Sonali, C Vichitra, T Sunanda… - Cells, 2022 - mdpi.com
Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-
negative bacteria. A growing body of evidence reveals that alterations in the bacterial …

Functional properties of spinach (Spinacia oleracea L.) phytochemicals and bioactives

JL Roberts, R Moreau - Food & function, 2016 - pubs.rsc.org
Overwhelming evidence indicates that diets rich in fruits and vegetables are protective
against common chronic diseases, such as cancer, obesity and cardiovascular disease …