DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …

Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …

Dynamic three-dimensional chromatin conformation is a critical mechanism for gene
regulation during development and disease. Despite this, profiling of three-dimensional …

The establishment of cell identity during embryonic development involves the activation of
specific gene expression programmes and is underpinned by epigenetic factors including …

CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being
associated with~ 70% of all gene promoters. CGIs control transcription initiation by …

The mammalian genome is depleted in CG dinucleotides, except at protected regions where
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …

The discovery of histone demethylases has revealed the dynamic nature of the regulation of
histone methylation. KDM2B is an important histone lysine demethylase that removes methyl …

We hypothesized that the highly controlled pattern of gene expression that is essential for
liver regeneration is encoded by an epigenetic code set in quiescent hepatocytes. Here we …

Despite numerous observations regarding the relationship between DNA methylation
changes and cancer progression, only a few genes have been verified as diagnostic …

Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …