Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

R Bai, J Guo, XY Ye, Y Xie, T Xie - Ageing research reviews, 2022 - Elsevier
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …

Molecular probes, chemosensors, and nanosensors for optical detection of biorelevant molecules and ions in aqueous media and biofluids

J Krämer, R Kang, LM Grimm, L De Cola… - Chemical …, 2022 - ACS Publications
Synthetic molecular probes, chemosensors, and nanosensors used in combination with
innovative assay protocols hold great potential for the development of robust, low-cost, and …

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease

T Guo, D Zhang, Y Zeng, TY Huang, H Xu… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Chemical design of activatable photoacoustic probes for precise biomedical applications

Y Liu, L Teng, B Yin, H Meng, X Yin, S Huan… - Chemical …, 2022 - ACS Publications
Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …

Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes

YL Qi, YZ Li, MJ Tan, FF Yuan, N Murthy… - Coordination Chemistry …, 2023 - Elsevier
The burgeoning organic near-infrared (NIR) ratiometric small-molecule fluorescent probes
with excellent merits have attracted great attention over the past few years. The traditional …

Current understanding of metal ions in the pathogenesis of Alzheimer's disease

L Wang, YL Yin, XZ Liu, P Shen, YG Zheng… - Translational …, 2020 - Springer
Background The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the
brain is crucial for maintaining normal physiological functions. Studies have shown that …

Oxidative stress occurs prior to amyloid Aβ plaque formation and tau phosphorylation in Alzheimer's disease: Role of glutathione and metal ions

RG Roy, PK Mandal, JC Maroon - ACS Chemical Neuroscience, 2023 - ACS Publications
Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …

The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators

LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Iron homeostasis disorder and Alzheimer's disease

Y Peng, X Chang, M Lang - International journal of molecular sciences, 2021 - mdpi.com
Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

Current strategies for modulating Aβ aggregation with multifunctional agents

Z Du, M Li, J Ren, X Qu - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Alzheimer's disease (AD), as the primary cause of dementia, has seriously
affected millions of people worldwide and brought a very heavy financial and social burden …