Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
to their families and causes a heavy socioeconomic burden to society. A vast amount of …
Molecular probes, chemosensors, and nanosensors for optical detection of biorelevant molecules and ions in aqueous media and biofluids
Synthetic molecular probes, chemosensors, and nanosensors used in combination with
innovative assay protocols hold great potential for the development of robust, low-cost, and …
innovative assay protocols hold great potential for the development of robust, low-cost, and …
Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …
dependent dementia. There is currently no effective treatment for AD, which may be …
Chemical design of activatable photoacoustic probes for precise biomedical applications
Y Liu, L Teng, B Yin, H Meng, X Yin, S Huan… - Chemical …, 2022 - ACS Publications
Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …
integrates the advantage of optical and acoustic imaging, has great application prospects in …
Recent advances in organic near-infrared ratiometric small-molecule fluorescent probes
The burgeoning organic near-infrared (NIR) ratiometric small-molecule fluorescent probes
with excellent merits have attracted great attention over the past few years. The traditional …
with excellent merits have attracted great attention over the past few years. The traditional …
Current understanding of metal ions in the pathogenesis of Alzheimer's disease
L Wang, YL Yin, XZ Liu, P Shen, YG Zheng… - Translational …, 2020 - Springer
Background The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the
brain is crucial for maintaining normal physiological functions. Studies have shown that …
brain is crucial for maintaining normal physiological functions. Studies have shown that …
Oxidative stress occurs prior to amyloid Aβ plaque formation and tau phosphorylation in Alzheimer's disease: Role of glutathione and metal ions
Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …
The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators
LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …
Iron homeostasis disorder and Alzheimer's disease
Y Peng, X Chang, M Lang - International journal of molecular sciences, 2021 - mdpi.com
Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …
Current strategies for modulating Aβ aggregation with multifunctional agents
Conspectus Alzheimer's disease (AD), as the primary cause of dementia, has seriously
affected millions of people worldwide and brought a very heavy financial and social burden …
affected millions of people worldwide and brought a very heavy financial and social burden …