Conventional tumor models have critical shortcomings in that they lack the complexity of the
human stroma. The heterogeneous stroma is a central compartment of the tumor …

With the increasing prevalence of type 2 diabetes and fatty liver disease, there is still an
unmet need to better treat hyperglycemia and hyperlipidemia. Here, we identify isthmin-1 …

Metformin is a widely prescribed anti-diabetic medicine that also reduces body weight.
There is ongoing debate about the mechanisms that mediate metformin's effects on energy …

Background Albumin is the most abundant protein in serum and serves as a transporter of
free fatty acids (FFA) in blood vessels. In type 2 diabetes mellitus (T2DM) patients, the …

Non-alcoholic fatty liver disease (NAFLD) has been shown to influence breast cancer
progression, but the underlying mechanisms remain unclear. In this study, we investigated …

Olanzapine is an atypical antipsychotic drug that is clinically applied in patients with
schizophrenia. It increases the risk of dyslipidemia, a disturbance of lipid metabolic …

METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m6A
modification to regulate gene expression. In addition, METTL3 regulates transcription in an …

Non-alcoholic fatty liver disease is a heterogeneous disease with unclear underlying
molecular mechanisms. Here, we perform single-cell RNA sequencing of hepatocytes and …

Introduction During thermogenesis, adipose tissue (AT) becomes more active and enhances
oxidative metabolism. The promotion of this process in white AT (WAT) is called “browning” …

Human genetics has been instrumental in identification of genetic variants linked to type 2
diabetes. Recently a rare, putative loss-of-function mutation in the orphan G-protein coupled …