Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

Cardiac stress can induce morphological, structural and functional changes of the heart,
referred to as cardiac remodeling. Myocardial infarction or sustained overload as a result of …

Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate
acute wound healing and long-term tissue remodeling with scarring. With myocardial …

Canonical roles for macrophages in mediating the fibrotic response after a heart attack
include extracellular matrix turnover and activation of cardiac fibroblasts to initiate collagen …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Myeloproliferative neoplasms are associated with increased risk for thrombotic
complications. These conditions most commonly involve somatic mutations in genes that …

In dramatic contrast to the poor repair outcomes for humans and rodent models such as
mice, salamanders and some fish species are able to completely regenerate heart tissue …

Abstract Purpose of Review Organ fibrosis is a lethal component of scleroderma. The
hallmark of scleroderma fibrosis is extensive extracellular matrix (ECM) deposition by …

Myocardial infarction is the most common form of acute cardiac injury attributing to heart
failure. While there have been significant advances in current therapies, mortality and …

Cardiovascular Disease (CVD) is the most common cause of death in industrialized
countries, and myocardial infarction (MI) is a major CVD with significant morbidity and …