Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and
is initially very responsive to platinum-based chemotherapy. However, the majority of …

Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Ribosomes are a complex ensemble of rRNA and ribosomal proteins that function as mRNA
translation machines. Ribosome biogenesis is a multistep process that begins in the …

Transcription of the ribosomal RNA genes (rDNA) that encode the three largest ribosomal
RNAs (rRNA), is mediated by RNA Polymerase I (Pol I) and is a key regulatory step for …

Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical
management of high grade serous ovarian cancer (HGSOC). Here, we demonstrate CX …

Ribosomes are nanomachines essential for protein production in all living cells. Ribosome
synthesis increases in cancer cells to cope with a rise in protein synthesis and sustain …

Cancer metastasis to distant organs is initiated by tumor cells that disseminate from primary
heterogeneous tumors. The subsequent growth and survival of tumor metastases depend on …

In the search for drugs to effectively treat cancer, the last 10 years have seen a resurgence
of interest in targeting ribosome biogenesis. CX-5461 is a potential inhibitor of ribosomal …

Ovarian cancer is the leading cause of death from gynecologic cancer worldwide. High-
grade serous carcinoma (HGSC) is the most common and deadliest subtype of ovarian …

Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology,
and biological feature. Despite accumulating understanding of OC in the post-genomic era …