Transient receptor potential (TRP) ion channels are sophisticated signaling machines that
detect a wide variety of environmental and physiological signals. Every cell in the body …

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel
that senses irritant chemicals. Its activation is closely associated with pain, inflammation, and …

Optimization of the catalyst structure to simultaneously improve multiple reaction objectives
(eg, yield, enantioselectivity, and regioselectivity) remains a formidable challenge. Herein …

C (sp3)-rich aliphatic motifs in drug molecules are strongly associated with clinical success.
Historically, the availability of compound libraries based on C (sp3)-rich cores has been …

The transient receptor potential channel subfamily A member 1 (TRPA1) ion channel is an
evolutionary conserved polymodal sensor responding to noxious temperature or chemical …

Oxidative stress damage is known as one of the important factors that induce neuropathic
pain (NP). Using antioxidant therapy usually achieves an obvious curative effect and …

1, 2, 4-Oxadiazole is an essential motif in drug discovery represented in many experimental,
investigational, and marketed drugs. This review covers synthetic methods that allow the …

Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium ion channel highly
expressed in the primary sensory neurons, functioning as a polymodal sensor for …

Transient receptor potential (TRP) channels are a large and diverse family of
transmembrane ion channels that are widely expressed, have important physiological roles …

Transient receptor potential ankyrin 1 (TRPA1) is a voltage-dependent, ligand-gated ion
channel, and activation thereof is linked to a variety of painful conditions. Preclinical studies …