Erythropoietin (EPO) as a key regulator of erythropoiesis, bone remodeling and endothelial transdifferentiation of multipotent mesenchymal stem cells (MSCs) …

AS Tsiftsoglou - Cells, 2021 - mdpi.com
Human erythropoietin (EPO) is an N-linked glycoprotein consisting of 166 aa that is
produced in the kidney during the adult life and acts both as a peptide hormone and …

Belzutifan: first approval

ED Deeks - Drugs, 2021 - Springer
Belzutifan (Welireg™) is an oral small molecule inhibitor of hypoxia-inducible factor (HIF)-2α
being developed by Peloton Therapeutics for the treatment of solid tumours, including renal …

The transcriptional and regulatory identity of erythropoietin producing cells

BK Kragesteen, A Giladi, E David, S Halevi… - Nature medicine, 2023 - nature.com
Erythropoietin (Epo) is the master regulator of erythropoiesis and oxygen homeostasis.
Despite its physiological importance, the molecular and genomic contexts of the cells …

Targeting the PI3K/Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: an emerging therapeutic strategy for type 1 diabetes

I Camaya, S Donnelly, B O'Brien - Journal of Diabetes, 2022 - Wiley Online Library
Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of the
insulin‐producing β‐cells within the pancreas. Islet transplantation represents one cure; …

The role of PI3K/AKT and MAPK signaling pathways in erythropoietin signalization

Z Tóthová, M Šemeláková, Z Solárová, J Tomc… - International Journal of …, 2021 - mdpi.com
Erythropoietin (EPO) is a glycoprotein cytokine known for its pleiotropic effects on various
types of cells and tissues. EPO and its receptor EPOR trigger signaling cascades …

[HTML][HTML] Erythropoietin regulation of red blood cell production: From bench to bedside and back

SV Bhoopalan, LJ Huang, MJ Weiss - F1000Research, 2020 - ncbi.nlm.nih.gov
More than 50 years of efforts to identify the major cytokine responsible for red blood cell
(RBC) production (erythropoiesis) led to the identification of erythropoietin (EPO) in 1977 …

Influence of COVID-19 on cerebrovascular disease and its possible mechanism

H Fan, X Tang, Y Song, P Liu… - … Disease and Treatment, 2020 - Taylor & Francis
The global spread of COVID-19 has caused a substantial societal burden and become a
major global public health issue. The COVID-19 elderly population with hypertension …

Silk fibroin/collagen/hydroxyapatite scaffolds obtained by 3D printing technology and loaded with recombinant human erythropoietin in the reconstruction of alveolar …

H Liu, C Wang, X Sun, C Zhan, Z Li, L Qiu… - ACS biomaterials …, 2022 - ACS Publications
The fast osteogenesis of the large alveolar fossa and the maintenance of the height of the
alveolar ridge after tooth extraction have always been a clinical challenge. Therefore, this …

Hypoxia-inducible factors signaling in osteogenesis and skeletal repair

Q Qin, Y Liu, Z Yang, M Aimaijiang, R Ma… - International Journal of …, 2022 - mdpi.com
Sufficient oxygen is required to maintain normal cellular and physiological function, such as
a creature's development, breeding, and homeostasis. Lately, some researchers have …

Erythropoietin as candidate for supportive treatment of severe COVID-19

H Ehrenreich, K Weissenborn, M Begemann… - Molecular …, 2020 - Springer
In light of the present therapeutic situation in COVID-19, any measure to improve course and
outcome of seriously affected individuals is of utmost importance. We recap here evidence …