Extracellular vesicles are released by the majority of cell types and circulate in body fluids.
They function as a long-distance cell-to-cell communication mechanism that modulates the …

During the past decade, extracellular vesicles (EVs), which include apoptotic bodies,
microvesicles, and exosomes, have emerged as important players in cell-to-cell …

The metastatic organotropism has been one of the cancer's greatest mysteries since the
'seed and soil'hypothesis. Although the role of EGFR in cancer cells is well studied, the …

Mesenchymal stem cells (MSCs) and macrophages are fundamental components of the
stem cell niche and function coordinately to regulate haematopoietic stem cell self-renewal …

The ability of cells to transmit bioactive molecules to recipient cells and the extracellular
environment is a fundamental requirement for both normal physiology and disease …

Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up
by recipient cells. Despite their discovery decades ago, it has only recently become …

The use of exosomes as a drug delivery vehicle has gained considerable interest. To
establish if exosomes could be utilized effectively for drug delivery, a better understanding of …

Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the
function of melanoma-derived exosomes in the formation of primary tumors and metastases …

Exosomes and microvesicles are extracellular nanovesicles released by most but not all
cells. They are specifically equipped to mediate intercellular communication via the transfer …

Harnessing exosomes as therapeutic drug delivery vehicles requires a better understanding
of exosomal composition and their mode of action. A full appreciation of all the exosomal …