BACKGROUND The defining feature of eukaryotic cells is the presence of membrane-bound
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …

The endoplasmic reticulum (ER) is the largest organelle in the cell, and its functions have
been studied for decades. The past several years have provided novel insights into the …

INTRODUCTION The cytoplasm contains an unconventional class of organelles that
concentrate specific factors and resources without a limiting membrane. These …

Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein
motors, which move in opposite directions along microtubules. This bidirectional cargo …

Summary Endocytic cargo and Rab GTPases are segregated to distinct domains of an
endosome. These domains maintain their identity until they undergo fission to traffic cargo. It …

The endoplasmic reticulum (ER) has a remarkably complex structure, composed of a single
bilayer that forms the nuclear envelope, along with a network of sheets and dynamic tubules …

Ribonucleoprotein (RNP) granules are enriched in specific RNAs and RNA-binding proteins
(RBPs) and mediate critical cellular processes. Purified RBPs form liquid droplets in vitro …

Organelles are dynamic yet highly organized to preserve cellular homeostasis. However, the
absence of time-resolved molecular tools for simultaneous dual-signal imaging of two …

Mitochondria form interconnected networks that dynamically remodel in response to cellular
needs. Using live-cell imaging, we investigate the role of the actin cytoskeleton in regulating …

The endocytic pathway is essential for processes that define how cells interact with their
environment, including receptor signalling, cell adhesion and migration, pathogen entry …