Gabapentinoids (eg pregabalin and gabapentin) are widely used in neurology, psychiatry
and primary healthcare but are increasingly being reported as possessing a potential for …

The treatment of opioid withdrawal is an important area of clinical concern when treating
patients with chronic, non-cancer pain, patients with active opioid use disorder, and patients …

Importance Guidelines recommend using gabapentin to decrease postoperative pain and
opioid use, but significant variation exists in clinical practice. Objective To determine the …

Opioid use disorder continues to be a significant source of morbidity and mortality in the
USA and the world. Pharmacologic treatment with methadone and buprenorphine has been …

Introduction: Alcohol misuse is the fifth leading risk factor for premature death and disability
worldwide. Fewer than 10% of afflicted Americans receive pharmacological treatment for …

Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat
restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed …

Objective: Gabapentin is commonly used off-label in the treatment of psychiatric disorders
with success, failure, and controversy. A systematic review of the literature was performed to …

Abstract Background North America continues to face an opioid overdose epidemic, driven
by persistent increases in illicit fentanyls and fluctuations in potency leading to uncertainty …

Background Previous studies demonstrate that the reformulation of OxyContin in the US in
2010 induced substitution to illicit opioids, causing illicit opioid markets to grow …

Detoxification refers to the safe discontinuation from a substance of dependence and is
distinct from relapse prevention. Detoxification usually takes between a few days and a few …