Cognitive and behavioural flexibility permit the appropriate adjustment of thoughts and
behaviours in response to changing environmental demands. Brain mechanisms enabling …

The availability of neuroimaging technology has spurred a marked increase in the human
cognitive neuroscience literature, including the study of cognitive ageing. Although there is a …

Aging is associated with performance decrements across multiple cognitive domains. The
neural noise hypothesis, a dominant view of the basis of this decline, posits that aging is …

Definitions of what constitutes the 'signal of interest'in neuroscience can be controversial,
due in part to continuously evolving notions regarding the significance of spontaneous …

Alterations in brain intrinsic activity—as organized in resting-state networks (RSNs) such as
sensorimotor network (SMN), salience network (SN), and default-mode network (DMN) …

A broad body of experimental work has demonstrated that apparently spontaneous brain
activity is not random. At the level of large-scale neural systems, as measured with functional …

Functional brain networks demonstrate significant temporal variability and dynamic
reconfiguration even in the resting state. Currently, most studies investigate temporal …

Neuroscientists have long observed that brain activity is naturally variable from moment-to-
moment, but neuroimaging research has largely ignored the potential importance of this …

As the global population ages, older decision makers will be required to take greater
responsibility for their own physical, psychological and financial well-being. With this in …

Functional connectivity (FC) as measured by correlation between fMRI BOLD time courses
of distinct brain regions has revealed meaningful organization of spontaneous fluctuations in …