Introduction: Identifying the optimized dosing regimen and algorithm is critical in the
development of antibiotics. Suboptimal regimens and inappropriate choice of drug give rise …

Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …

Background Antibiotic resistance is a threat to global health security. We assessed
knowledge, attitudes, and practices in regard to antibiotic prescribing and resistance in …

Most studies to evaluate kidney safety biomarkers have been performed in rats. This study
was conducted in Cynomolgus monkeys in order to evaluate the potential usefulness of …

Objectives Gentamicin is widely used in end-stage renal disease (ESRD) patients for the
treatment of infections. The goal of this study was to find the most reasonable dosing …

Background Gentamicin is an aminoglycoside antimicrobial commonly used in horses at 6.6
mg/kg IV once daily. Therapeutic drug monitoring (TDM) can confirm desired peak …

Background Premature, very low birth weight (VLBW) neonates are at risk for early-onset
sepsis and receive ampicillin and gentamicin post-birth. Antimicrobial stewardship supports …

Background Although the once-daily regimen of aminoglycosides (AG) is considered as
predominantly used by many centers, the level of evidence of Therapeutic Drug Monitoring …

The therapeutic efficacy of antibiotics is very dependent not only on the drug itself but also
on whether there is enough drug concentration at the site of infection for a sufficient amount …

Objectives The optimal dosage regimen of gentamicin in horses is still under investigation.
The objectives of this study were to determine gentamicin plasma concentrations in …