HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation
MA Checkley, BG Luttge, EO Freed - Journal of molecular biology, 2011 - Elsevier
The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …
by mediating the fusion between viral and cellular membranes during the entry process. The …
Membrane budding
Membrane budding is a key step in vesicular transport, multivesicular body biogenesis, and
enveloped virus release. These events range from those that are primarily protein driven …
enveloped virus release. These events range from those that are primarily protein driven …
Membrane phase separation drives responsive assembly of receptor signaling domains
SA Shelby, I Castello-Serrano, KC Wisser… - Nature Chemical …, 2023 - nature.com
Plasma membrane heterogeneity has been tied to a litany of cellular functions and is often
explained by analogy to membrane phase separation; however, models based on phase …
explained by analogy to membrane phase separation; however, models based on phase …
Neutral sphingomyelinase 2 is required for HIV-1 maturation
AA Waheed, Y Zhu, E Agostino… - Proceedings of the …, 2023 - National Acad Sciences
HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered
membrane microdomains. The size and stability of membrane microdomains is regulated by …
membrane microdomains. The size and stability of membrane microdomains is regulated by …
Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound
Although HIV-1 Gag is known to drive viral assembly and budding, the precise mechanisms
by which the lipid composition of the plasma membrane is remodeled during assembly are …
by which the lipid composition of the plasma membrane is remodeled during assembly are …
Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides
Retroviruses acquire a lipid envelope during budding from the membrane of their hosts.
Therefore, the composition of this envelope can provide important information about the …
Therefore, the composition of this envelope can provide important information about the …
Dynamics of HIV-1 assembly and release
S Ivanchenko, WJ Godinez, M Lampe… - PLoS …, 2009 - journals.plos.org
Assembly and release of human immunodeficiency virus (HIV) occur at the plasma
membrane of infected cells and are driven by the Gag polyprotein. Previous studies …
membrane of infected cells and are driven by the Gag polyprotein. Previous studies …
The lipid raft hypothesis revisited–New insights on raft composition and function from super‐resolution fluorescence microscopy
Recently developed super‐resolution microscopy techniques are changing our
understanding of lipid rafts and membrane organisation in general. The lipid raft hypothesis …
understanding of lipid rafts and membrane organisation in general. The lipid raft hypothesis …
Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4, 5)-bisphosphate is essential for efficient gag membrane …
V Chukkapalli, IB Hogue, V Boyko, WS Hu… - Journal of …, 2008 - Am Soc Microbiol
Human immunodeficiency virus type 1 (HIV-1) particle assembly mediated by the viral
structural protein Gag occurs predominantly on the plasma membrane (PM). Although it is …
structural protein Gag occurs predominantly on the plasma membrane (PM). Although it is …
[HTML][HTML] More than one door–budding of enveloped viruses through cellular membranes
S Welsch, B Müller, HG Kräusslich - Febs Letters, 2007 - Elsevier
Enveloped viruses exit their host cell by budding from a cellular membrane and thereby
spread from one cell to another. Virus budding in general involves the distortion of a cellular …
spread from one cell to another. Virus budding in general involves the distortion of a cellular …