EXECUTIVE SUMMARY The University of Vermont College of Medicine and the Vermont
Lung Center, with support of the National Heart, Lung, and Blood Institute (NHLBI), the …

Mesenchymal stem cells (MSCs) are adult multipotent cells that due to their ability to homing
to damaged tissues and differentiate into specialized cells, are remarkable cells in the field …

Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by
the histopathological pattern of usual interstitial pneumonia and is associated with a high …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible lung disease of
unknown cause. It has been reported that both lung resident mesenchymal stem cells (LR …

An emerging paradigm proposes a crucial role for lung resident mesenchymal stem cells
(LR-MSCs) via a fibroblastic transdifferentiation event in the pathogenesis of idiopathic …

Cells demonstrate plasticity following injury, but the extent of this phenomenon and the
cellular mechanisms involved remain underexplored. Using single-cell RNA sequencing …

Resident stem/progenitor cells in the lung are important for tissue homeostasis and repair.
However, a progenitor population for alveolar type II (ATII) cells in adult human lungs has …

The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or
insult, a specialised group of facultative lung progenitors become activated to replenish …

While multipotent mesenchymal stromal cells have been recently isolated from adult lung (L-
MSCs), there is very limited data on their biological properties and therapeutic potential in …

Lung-resident mesenchymal stem cells (LR-MSCs) are important regulators of lung repair
and regeneration, and evidence suggests that this cell population also plays a vital role in …