The molecules known as bis (thiosemicarbazones) derived from 1, 2-diones can act as
tetradentate ligands for Cu (II), forming stable, neutral complexes. As a family, these …

Alzheimer's disease is the most common form of age-related neurodegenerative dementia.
The disease is characterised by the presence of plaques in the cerebral cortex. The major …

The microPET Primate 4-ring system (P4) is an animal PET tomograph with a 7.8 cm axial
extent, a 19 cm diameter transaxial field of view (FOV) and a 22 cm animal port. The system …

Generator-derived radionuclides for PET/CT imaging are promising for optimizing targeted
radiotherapy by an individual patient-based approach, applying pre-therapeutic evaluation …

Copper has several clinically relevant radioisotopes and versatile coordination chemistry,
allowing attachment of its radionuclides to biological molecules. This characteristic makes it …

Targeted molecular imaging with positron emission tomography (PET) constitutes a
successful technique for detecting and diagnosing disease conditions promptly and …

Purpose PET radiotracers which incorporate longer-lived radionuclides enable biological
processes to be studied over many hours, at centres remote from a cyclotron. This paper …

Radionuclide generator systems continue to play a key role in providing both diagnostic and
therapeutic radionuclides for various applications in nuclear medicine, oncology, and …

Increasing the potency of therapeutic compounds, while limiting side-effects, is a common
goal in medicinal chemistry. Ligands that effectively bind metal ions and also include …

Alzheimer's disease can involve brain copper dyshomeostasis. We aimed to determine the
effect of AD-like pathology on 64Cu trafficking in mice, using positron emission tomography …