Diminished oxygen availability, termed hypoxia, within solid tumors is one of the most
common characteristics of cancer. Hypoxia shapes the landscape of the tumor …

Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN–
pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation …

The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more
pathway components and in more tumor types than any other growth factor signaling …

Many cancer cells are characterized by increased glycolysis and decreased respiration,
even under aerobic conditions. The molecular mechanisms underlying this metabolic …

Abstract The von Hippel–Lindau disease is caused by inactivating germline mutations of the
VHL tumour suppressor gene and is associated with an increased risk of a variety of …

In more recent years, long non‐coding RNAs (lncRNAs) have been investigated as a new
class of regulators of cellular processes, such as cell growth, apoptosis, and carcinogenesis …

Hypoxic and VHL-deficient cells use glutamine to generate citrate and lipids through
reductive carboxylation (RC) of α-ketoglutarate. To gain insights into the role of HIF and the …

MEG3 is a maternally expressed imprinted gene suggested to function as a non-coding
RNA. Our previous studies suggest that MEG3 has a function of tumor suppression. The …

The tumor suppressor p53 is central to many cellular stress responses. Although numerous
protein factors that control p53 have been identified, the role of microRNAs (miRNAs) in …