The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by
medicinal chemists to obtain compounds for the treatment of human diseases. The great …

Nitrogen containing heterocycles are of immense research interest because they are often
found as naturally occurring bioactive compounds. The prominence of N-heterocycles …

Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as
they display vast biological activities. Recent efforts concerning the preparation of oxindole …

Spirocompounds constitute an important class of organic frameworks enveloping numerous
pharmacological activities, among them, the promising anticancer potential of …

Pyrrolidine molecules are a significant class of synthetic and natural plant metabolites,
which show the diversity of pharmacological activities. An extensive variety of synthetic …

Over the last three decades, the scaffold proteins prohibitins-1 and-2 (PHB1/2) have
emerged as key signaling proteins regulating a myriad of signaling pathways in health and …

Small-molecule (SM) leads in the early drug discovery pipeline are progressed primarily
based on potency against the intended target (s) and selectivity against a very narrow slice …

This review aimed at summarizing the literature pertaining to the biological activities of
pyrrolidine alkaloids and their derivatives obtained from various sources. For this purpose …

Great strides have been made in triple negative breast cancer (TNBC) treatment, which
represents 20% of total predicted annual US breast cancer (BC) cases. Despite the …

The U rhynchophylla, U tomentosa, Isatis indigotica Fortune, Voacanga Africana, herbal
constituents, fungal extracts from Aspergillus duricaulis culture media, include …