α-Synuclein (αS) is a small, unstructured, presynaptic protein expressed in the brain. Its
aggregated form is a major component of Lewy bodies, the large proteinaceous deposits in …

Alpha-synuclein positive-intracytoplasmic inclusions are the common denominators of the
synucleinopathies present as Lewy bodies in Parkinson's disease, dementia with Lewy …

Recent evidence has emphasized soluble species of amyloid-β (Aβ) and tau as pathogenic
effectors in Alzheimer's disease (AD). Despite the fact that Aβ, tau, and α-synuclein (αSyn) …

The Negatome is a collection of protein and domain pairs that are unlikely to be engaged in
direct physical interactions. The database currently contains experimentally supported non …

Synucleins are small, soluble proteins expressed primarily in neural tissues and certain
tumors. The family includes three known proteins: α‐synuclein, β‐synuclein, and γ …

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons from the
substantia nigra (SN) that project to the dorsal striatum (caudate-putamen). To better …

Epidemiological evidence suggests a reduced incidence of many common types of non-
smoking-related cancers in individuals with Parkinson's disease (PD). Genes that underlie …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar
aggregates of α-synuclein in characteristic inclusions known as 'Lewy bodies'. As mutations …

α-Synuclein appears to play a role in mediating neurotoxicity in a number of
neurodegenerative disorders, collectively referred to as synucleinopathies. Most of these …

Alzheimer's disease (AD) is a heterogeneous age-dependent neurodegenerative disorder.
Its hallmarks involve abnormal proteostasis, which triggers proteotoxicity and induces …