The “missing heritability”—Problem in psychiatry: Is the interaction of genetics, epigenetics and transposable elements a potential solution?

D van Calker, T Serchov - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Psychiatric disorders exhibit an enormous burden on the health care systems worldwide
accounting for around one-third of years lost due to disability among adults. Their etiology is …

Can Epigenetics Predict Drug Efficiency in Mental Disorders?

G Ben David, Y Amir, R Salalha, L Sharvit… - Cells, 2023 - mdpi.com
Psychiatric disorders affect millions of individuals and their families worldwide, and the costs
to society are substantial and are expected to rise due to a lack of effective treatments …

Ceremonial ayahuasca in amazonian retreats—mental health and epigenetic outcomes from a six-month naturalistic study

SGD Ruffell, N Netzband, WF Tsang, M Davies… - Frontiers in …, 2021 - frontiersin.org
Ayahuasca is a natural psychoactive brew, used in traditional ceremonies in the Amazon
basin. Recent research has indicated that ayahuasca is pharmacologically safe and its use …

[HTML][HTML] Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia

J Teeuw, APS Ori, RM Brouwer, SMC de Zwarte… - Schizophrenia …, 2021 - Elsevier
Schizophrenia patients show signs of accelerated aging in cognitive and physiological
domains. Both schizophrenia and accelerated aging, as measured by MRI brain images and …

Conserved DNA Methylation Signatures in Early Maternal Separation and in Twins Discordant for CO2 Sensitivity

F Giannese, A Luchetti, G Barbiera, V Lampis… - Scientific reports, 2018 - nature.com
Respiratory and emotional responses to blood-acidifying inhalation of CO2 are markers of
some human anxiety disorders, and can be enhanced by repeatedly cross-fostering (RCF) …

Rethinking the epigenetic framework to unravel the molecular pathology of schizophrenia

A Cariaga-Martinez, R Alelú-Paz - International Journal of Molecular …, 2017 - mdpi.com
Schizophrenia is a complex mental disorder whose causes are still far from being known.
Although researchers have focused on genetic or environmental contributions to the …

[HTML][HTML] A characteristic cerebellar biosignature for bipolar disorder, identified with fully automatic machine learning

GV Thomaidis, K Papadimitriou, S Michos… - IBRO Neuroscience …, 2023 - Elsevier
Background Transcriptomic profile differences between patients with bipolar disorder and
healthy controls can be identified using machine learning and can provide information about …

Epigenetic and schizophrenia

A Cariaga-Martinez, R Alelú-Paz - Psychotic disorders-An …, 2018 - books.google.com
Schizophrenia is a complex psychiatric disorder characterised by the presence of positive,
negative and cognitive symptoms that lack a unifying neuropathology. The absence of …

Identifying Bipolar patients from controls, using post-mortem cerebellum gene expression data and fully Automated Machine Learning

GV Thomaidis, S Michos, K Papadimitriou… - medRxiv, 2022 - medrxiv.org
Objective Complex machine learning classification algorithms using transcriptome data from
post-mortem cerebellar tissue of bipolar patients and unaffected controls, have been …

[PDF][PDF] Rethinking schizophrenia through the lens of evolution: shedding light on the enigma

A Cariaga-Martinez, K Gutiérrez… - Research Ideas and …, 2018 - riojournal.com
Schizophrenia refers to a complex psychiatric illness characterized by the heterogenic
presence of positive, negative and cognitive symptoms occurring in all human societies. The …