RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …

Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …

Adult stem cells ensure tissue homeostasis and regeneration after injury. Due to their
longevity and functional requirements, throughout their life stem cells are subject to a …

Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …

Bi-directional transcription of Human Endogenous Retroviruses (hERVs) is a common
feature of autoimmunity, neurodegeneration and cancer. Higher rates of cancer incidence …

RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …

Endogenous retroelements are DNA sequences which can duplicate and move to new
locations in the genome. Actively moving endogenous retroelements can be disruptive to the …

In recent years, there has been significant progress toward understanding the transcriptional
networks underlying mammalian immune responses, fueled by advances in regulatory …

Hematopoietic stem and progenitor cells (HSPCs) are a heterogeneous group of cells with
expansion, differentiation, and repopulation capacities. How HSPCs orchestrate the …

Hematopoietic stem cells (HSCs) have the properties to self-renew and/or differentiate into
any blood cell lineages. In order to balance the maintenance of the stem cell pool with …