Cancer genetics has led to major discoveries, including protooncogene and tumor‐
suppressor concepts, and cancer genomics generated concepts like driver and passenger …

Radical prostatectomy is the gold standard treatment for prostate cancer (PCa); however, it
does not always completely cure PCa, and patients often experience a recurrence of the …

Abstract Polo-like kinase 1 (PLK1) inhibitors have had limited antitumor efficacy as single
agents, and a focus of current efforts is on combination therapies. We initially confirmed that …

Background Introns are generally removed from primary transcripts to form mature RNA
molecules in a post-transcriptional process called splicing. An efficient splicing of primary …

The androgen receptor (AR) is the central determinant of prostate tissue identity and
differentiation, controlling normal, growth-suppressive prostate-specific gene expression. It …

Background: The incidence of prostate cancer (PC) exhibits geographical heterogeneity.
However, the metabolic mechanisms underlying this geographic heterogeneity remain …

Background/Objectives: Cancer is caused by disruptions in the homeostatic state of normal
cells, which results in dysregulation of the cell cycle, and uncontrolled growth and …

Background: Modeling the pathophysiology of prostate cancer (PCa) remains a challenge
and primary tissue-derived organoid cultures have emerged as promising models …

Eukaryotic genes are mostly composed of a series of exons intercalated by sequences with
no coding potential called introns. These sequences are generally removed from primary …