O‐GlcNAcylation: cellular physiology and therapeutic target for human diseases

L Ye, W Ding, D Xiao, Y Jia, Z Zhao, X Ao, J Wang - MedComm, 2023 - Wiley Online Library
Abstract O‐linked‐β‐N‐acetylglucosamine (O‐GlcNAcylation) is a distinctive
posttranslational protein modification involving the coordinated action of O‐GlcNAc …

The O-GlcNAc dichotomy: when does adaptation become pathological?

TJ Costa, EW Wilson, MT Fontes, L Pernomian… - Clinical …, 2023 - portlandpress.com
O-Linked attachment of β-N-acetylglucosamine (O-GlcNAc) on serine and threonine
residues of nuclear, cytoplasmic, and mitochondrial proteins is a highly dynamic and …

Cardioprotective O-GlcNAc signaling is elevated in murine female hearts via enhanced O-GlcNAc transferase activity

B Narayanan, P Sinha, R Henry, RA Reeves… - Journal of Biological …, 2023 - ASBMB
The post-translational modification of intracellular proteins by O-linked β-GlcNAc (O-GlcNAc)
has emerged as a critical regulator of cardiac function. Enhanced O-GlcNAcylation activates …

Caveolin-1/Endothelial nitric oxide synthase interaction is reduced in arteries from pregnant spontaneously hypertensive rats

JA Troiano, SR Potje, ME Graton, ET Gonçalves… - Frontiers in …, 2021 - frontiersin.org
We have investigated the role caveolae/caveolin-1 (Cav-1) plays in endothelial nitric oxide
synthase (eNOS) activation and how it impacts pregnancy-induced decreased vascular …

Physiological and pathological evidence of O-GlcNAcylation regulation during pregnancy related process

M de Lima Castro, RR Dos Passos Jr, VD Justina… - Placenta, 2023 - Elsevier
O-GlcNAcylation is a dynamic and reversible post-translational modification (PTM)
controlled by the enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Changes …