Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of
serine protease inhibitors, serpins. It was first identified as a neuronal differentiating factor …

Simple Summary The ongoing clinical need to improve cancer therapies warrants a better
understanding of the mechanisms behind cancer growth and its spread to distant organs. To …

Simple Summary While more efficient cancer treatments have led to a better quality of life
and to five-year survival rates of over 85% for localized tumors, these rates remain below …

Mammary gland hyperplasia (MGH) is a common mammary disease whose main
pathogenesis is the disruption of estradiol (E2) and progesterone (P) secretion, thereby …

Background Virginal breast hypertrophy is a rapid and massive enlargement of one or both
breasts. There are several proposed causes and treatment options for virginal breast …

Reproductive aging is characterized by a decline in ovarian function and in oocytes' quantity
and quality. Pigment epithelium-derived factor (PEDF), a pivotal player in ovarian …

We discovered that pigment epithelium-derived factor (PEDF)–null mice have endometrial
hyperplasia, the precursor to human type I endometrial cancer (ECA), which is etiologically …

Research question Does recombinant pigment epithelium derived factor (PEDF) have
potential in treating uterine fibroids? Design In-vitro models that used human leiomyoma …

Tamoxifen is the most common adjuvant that has been widely used in the treatment of
positive estrogen receptor (ER+) breast cancer for over 20 years. However, long term …

Reproductive aging is a biological phenomenon that is seen in women, noted by a
progressive decline in ovarian function and a decrease in both the quantity and quality of …