As the repository of genetic information, the cell nucleus must protect DNA integrity from
mechanical stresses. The nuclear lamina, which resides within the nuclear envelope (NE), is …

MeCP2 protein, encoded by the MECP2 gene, binds to DNA and affects transcription.
Outside of this activity the true range of MeCP2 function is still not entirely clear. As MECP2 …

Loss-of-function mutations in MECP2 cause Rett syndrome (RTT), a severe neurological
disorder that mainly affects girls. Mutations in MECP2 do occur in males occasionally and …

Heterochromatin is the highly compacted form of chromatin with various condensation levels
hallmarked by high DNA methylation. MeCP2 is mostly known as a DNA methylation reader …

Rett syndrome is a devastating childhood neurological disorder caused by mutations in
MECP2. Of the many symptoms, motor deterioration is a significant problem for patients. In …

The “AT-hook” is a peculiar DNA-binding domain that interacts with DNA in the minor groove
in correspondence to AT-rich sequences. This domain has been first described in the HMGA …

Abstract 3D organization of the genome plays a critical role in regulating gene expression.
However, it remains unclear how chromatin organization differs among different cell types in …

Correlative evidence has suggested that the methyl-CpG-binding protein MeCP2 contributes
to the formation of heterochromatin condensates via liquid-liquid phase separation. This …

Abstract Methyl CpG binding protein 2 (MeCP2) is involved in nerve regeneration following
ischemic stroke, but the related mechanism remains unclear. Here, we found low MeCP2 …

Mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene cause Rett
syndrome, a severe childhood neurological disorder. MeCP2 is a well-established …