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Most patients with ischaemic stroke are managed on the ward or in specialty stroke units, but
a significant number requires higher-acuity care and, consequently, admission to the …

Background and Purpose—The authors present an overview of the current evidence and
management recommendations for evaluation and treatment of adults with acute ischemic …

An association between hypoxemia and poor outcomes from traumatic brain injury (TBI) is
well documented. However, it is unclear whether hyperoxygenation is beneficial. This …

Although hyperoxia has not been conclusively identified as a clinically important cause of
lung injury in humans, animal data strongly implicate it. Reports of interaction effects …

Early blood–brain barrier (BBB) disruption resulting from excessive neurovascular
proteolysis by matrix metalloproteinases (MMPs) is closely associated with hemorrhagic …

Background and Purpose—Early neurological deterioration (END) is a relatively common
unfavorable course after anterior circulation ischemic stroke that can lead to worse clinical …

Normobaric hyperoxia is under investigation as a treatment for acute ischaemic stroke. In
experimental models, normobaric hyperoxia reduces cerebral ischaemic injury and …

Preventing death and limiting handicap from ischaemic stroke are major goals that can be
achieved only if the pathophysiology of infarct expansion is properly understood. Primate …

Background and Objectives To investigate the safety and efficacy of normobaric hyperoxia
(NBO) combined with endovascular treatment (EVT) in patients with acute ischemic stroke …