Over the last decade, precision medicine and immunotherapeutic approaches have become
increasingly popular in oncology. Early clinical trials reported promising results, but …

Genome-wide association studies (GWASs) have shown a large number of genetic variants
to be associated with complex diseases. The identification of the causal variant within an …

This article reviews the production of different phenotypes from the same genotype in the
same environment by stochastic cellular events, nonlinear mechanisms during patterning …

Advances in genomic technology have enabled the faithful detection and measurement of
mutations and the gene expression profile of cancer cells at the single-cell level. Recently …

Single-cell DNA sequencing has great potential to reveal the clonal genotypes and
population structure of human cancers. However, single-cell data suffer from missing values …

It's been over 100 years since the wordgene'is around and progressively evolving in several
scientific directions. Time-to-time technological advancements have heavily revolutionized …

Single-cell genomic analysis has grown rapidly in recent years and finds widespread
applications in various fields of biology, including cancer biology, development …

The development of a metastatic disease is recognised as the cause of death of over 90% of
patients diagnosed with cancer. Understanding the biological features of metastasis has …

Single cell Chelex® DNA extraction and nested PCR amplification were used to examine
partial gene sequences from natural diatom populations for taxonomic and phylogenetic …

Single cell analysis is an essential research approach to reveal the secret of life. At such a
small scale, it puts forward higher demand on the accuracy of the cell manipulation system …