Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease

NM Lyra e Silva, RA Gonçalves, TA Pascoal… - Translational …, 2021 - nature.com
Alzheimer's disease (AD) is associated with memory impairment and altered peripheral
metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery …

Type 3 diabetes and its role implications in Alzheimer's disease

TT Nguyen, QTH Ta, TKO Nguyen… - International journal of …, 2020 - mdpi.com
The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in
debate. However, poorly controlled blood sugar may increase the risk of developing …

Brain insulin signalling in metabolic homeostasis and disease

T Scherer, K Sakamoto, C Buettner - Nature Reviews Endocrinology, 2021 - nature.com
Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

The critical role of the branched chain amino acids (BCAAs) catabolism-regulating enzymes, branched-chain aminotransferase (BCAT) and branched-chain α-keto …

A Dimou, V Tsimihodimos, E Bairaktari - International Journal of …, 2022 - mdpi.com
Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are essential amino
acids widely studied for their crucial role in the regulation of protein synthesis mainly through …

Type 2 diabetes mellitus and Alzheimer's disease: shared molecular mechanisms and potential common therapeutic targets

R Hamzé, E Delangre, S Tolu, M Moreau… - International journal of …, 2022 - mdpi.com
The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly
with the aging of the population. Numerous epidemiological data suggest that there is a …

Altered gut microbiota in a mouse model of Alzheimer's disease

L Zhang, Y Wang, X Xiayu, C Shi… - Journal of …, 2017 - content.iospress.com
The topic of gut microbiota is currently attracting considerable interest as a potential factor in
Alzheimer's disease (AD). However, the extent and time course of alterations in the gut …

Inflammatory pathways in Alzheimer's disease mediated by gut microbiota

X Qian, X Song, X Liu, H Tang - Ageing research reviews, 2021 - Elsevier
In the past decade, numerous studies have demonstrated the close relationship between gut
microbiota and the occurrence and development of Alzheimer's disease (AD). However, the …

The therapeutic potential of metformin in neurodegenerative diseases

C Rotermund, G Machetanz… - Frontiers in endocrinology, 2018 - frontiersin.org
The search for treatments for neurodegenerative diseases is a major concern in light of
today's aging population and an increasing burden on individuals, families, and society …