Mechanisms in endocrinology: Ghrelin: the differences between acyl-and des-acyl ghrelin

PJD Delhanty, SJ Neggers… - European journal of …, 2012 - academic.oup.com
Des-acyl ghrelin (DAG) is one of the three preproghrelin gene-encoded peptides. Compared
with ghrelin and obestatin, it has not received the attention it deserves. DAG has long been …

A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS

CR Triggle, H Ding - Journal of the American Society of Hypertension, 2010 - Elsevier
Although the etiology of vascular dysfunction in diabetes has been extensively investigated
in both humans as well as animal models of human diabetes, the relative importance of the …

Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do?

PJD Delhanty, SJ Neggers… - How Gut and Brain Control …, 2014 - karger.com
The peptides ghrelin (or acyl ghrelin; AG), des-acyl ghrelin (DAG) and obestatin are all
encoded by the prepro-ghrelin gene that is expressed predominantly in the stomach …

Des-acyl ghrelin has specific binding sites and different metabolic effects from ghrelin in cardiomyocytes

PV Lear, MJ Iglesias, S Feijóo-Bandín… - …, 2010 - academic.oup.com
The current study aimed to compare the effects of the peptide hormone ghrelin and des-G,
its unacylated isoform, on glucose and fatty acid uptake and to identify des-G-specific …

Desacyl-ghrelin, not just an inactive form of ghrelin?-A review of current knowledge on the biological actions of desacyl-ghrelin

H Iwakura, T Ensho, Y Ueda - Peptides, 2023 - Elsevier
Desacyl-ghrelin is a form of ghrelin which lacks acyl-modification of the third serine residue
of ghrelin. Originally, desacyl-ghrelin was considered to be just an inactive form of ghrelin …

G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity

MR Meyer, NC Fredette, M Barton… - Journal of …, 2015 - joe.bioscientifica.com
In larger mammals, thyroid hormone-binding plasma proteins are albumin, transthyretin
(TTR) and thyroxine (T4)-binding globulin. They differ characteristically in affinities and …

Integrating GHS into the ghrelin system

JD Veldhuis, CY Bowers - International journal of peptides, 2010 - Wiley Online Library
Oligopeptide derivatives of metenkephalin were found to stimulate growth‐hormone (GH)
release directly by pituitary somatotrope cells in vitro in 1977. Members of this class of …

Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor (s)

JM Ku, ZB Andrews, T Barsby, A Reichenbach… - …, 2015 - academic.oup.com
The ghrelin-related peptides, acylated ghrelin, des-acylated ghrelin, and obestatin, are
novel gastrointestinal hormones. We firstly investigated whether the ghrelin gene, ghrelin O …

Contrasting effects of ghrelin and des‐acyl ghrelin on the lumbo‐sacral defecation center and regulation of colorectal motility in rats

H Hirayama, T Shiina, T Shima… - …, 2010 - Wiley Online Library
Background We have previously demonstrated that a centrally penetrant ghrelin receptor
agonist enhances colorectal motility, through activation of the lumbo‐sacral defecation …

Unacylated ghrelin improves vascular dysfunction and attenuates atherosclerosis during high-fat diet consumption in rodents

M Zanetti, G Gortan Cappellari, A Graziani… - International journal of …, 2019 - mdpi.com
Unacylated ghrelin (UnGhr) exerts several beneficial actions on vascular function. The aim
of this study was to assess the effects of UnGhr on high-fat induced endothelial dysfunction …