Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis

R Pratap, VJ Ram - Chemical reviews, 2014 - ACS Publications
1. INTRODUCTION Bicyclic oxygen heterocycles resulting from fusion of benzene ring with
5, 6-positions of either 2H-or 4H-pyran ring system are designated as 2H-chromene (2H-1 …

Antimalarial application of quinones: A recent update

OPS Patel, RM Beteck, LJ Legoabe - European Journal of Medicinal …, 2021 - Elsevier
Atovaquone belongs to a naphthoquinone class of drugs and is used in combination with
proguanil (Malarone) for the treatment of acute, uncomplicated malaria caused by …

Facile and One-Pot Access to Diverse and Densely Functionalized 2-Amino-3-cyano-4H-pyrans and Pyran-Annulated Heterocyclic Scaffolds via an Eco-Friendly …

G Brahmachari, B Banerjee - ACS Sustainable Chemistry & …, 2014 - ACS Publications
A simple, straightforward, and highly efficient multicomponent one-pot synthesis of a
pharmaceutically interesting diverse kind of functionalized 2-amino-3-cyano-4 H-pyrans and …

DBU: a highly efficient catalyst for one-pot synthesis of substituted 3, 4-dihydropyrano [3, 2-c] chromenes, dihydropyrano [4, 3-b] pyranes, 2-amino-4H-benzo [h] …

JM Khurana, B Nand, P Saluja - Tetrahedron, 2010 - Elsevier
We have reported DBU catalyzed one-pot synthesis of 3, 4-dihydropyrano [3, 2-c]
chromenes, dihydropyrano [4, 3-b] pyranes, 2-amino-4H-benzo [h] chromenes and 2-amino …

Green synthetic approaches for biologically relevant 2-amino-4H-pyrans and 2-amino-4H-pyran-annulated heterocycles in aqueous media

G Brahmachari - Green synthetic approaches for biologically relevant …, 2021 - Elsevier
Abstract 4H-Pyrans and 4H-pyran-annulated heterocyclic scaffolds represent a “privileged”
structural motif well-distributed in biologically active natural products and also in promising …

One-pot synthesis of dihydropyrano [2, 3-c] chromenes via a three component coupling of aromatic aldehydes, malononitrile, and 3-hydroxycoumarin catalyzed by …

S Paul, P Bhattacharyya, AR Das - Tetrahedron Letters, 2011 - Elsevier
An efficient and green protocol for the synthesis of dihydropyrano [2, 3-c] chromene
derivatives by one-pot, three component coupling reaction of aromatic aldehyde …

Chiral alkyl halides: Underexplored motifs in medicine

B Gál, C Bucher, NZ Burns - Marine drugs, 2016 - mdpi.com
While alkyl halides are valuable intermediates in synthetic organic chemistry, their use as
bioactive motifs in drug discovery and medicinal chemistry is rare in comparison. This is …

Novel One-Pot Three- and Pseudo-Five-Component Reactions: Synthesis of Functionalized Benzo[g]- and Dihydropyrano[2,3-g]chromene Derivatives

A Shaabani, R Ghadari, S Ghasemi… - Journal of …, 2009 - ACS Publications
A novel and efficient method has been developed for the synthesis of highly functionalized
benzo [g]-and dihydropyrano [2, 3-g] chromene derivatives via addition and subsequently …

Synthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell line

E Pérez-Sacau, RG Díaz-Peñate… - Journal of medicinal …, 2007 - ACS Publications
Catalyst/HypoGen pharmacophore modeling approach and three-dimensional quantitative
structure− activity relationship (3D-QSAR)/comparative molecular similarity indices analysis …

Facile and Chemically Sustainable One‐Pot Synthesis of a Wide Array of Fused O‐ and N‐Heterocycles Catalyzed by Trisodium Citrate Dihydrate under Ambient …

G Brahmachari, B Banerjee - Asian Journal of Organic …, 2016 - Wiley Online Library
A simple, straightforward, and highly efficient multicomponent one‐pot synthesis of
pharmaceutically interesting diverse functionalized O‐and N‐heterocyclic scaffolds, such as …