According to the traditional model, steroid hormones bind to intracellular receptors and
subsequently modulate transcription and protein synthesis, thus triggering genomic events …

Over the past decade, it has become clear that the brain is a steroidogenic organ. The
steroids synthesized by the brain and nervous system, given the name neurosteroids, have …

Lösel, Ralf M., Elisabeth Falkenstein, Martin Feuring, Armin Schultz, Hanns-Christian
Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action …

Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …

When administered intracerebroventricularly to mice performing various learning tasks
involving either short-term or long-term memory, secreted forms of the β-amyloid precursor …

This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …

Without medical progress, dementing diseases such as Alzheimer's disease will become
one of the main causes of disability. Preventing or delaying them has thus become a real …

Steroids, synthesized in peripheral glands or centrally in the brain—the latter being named
neurosteroids—exert an important role as modulators of the neuronal activity by interacting …

The neurosteroid pregnenolone and its sulfated derivative enhance learning and memory in
rodents. Pregnenolone sulfate also positively modulates NMDA receptors and could thus …

Emerging preclinical and clinical evidence suggests that pregnenolone may be a promising
novel therapeutic candidate in schizophrenia. Pregnenolone is a neurosteroid with …