Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …

Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …

This American Association for the Study of Liver Diseases (AASLD) 2018 Practice Guidance
on Primary Biliary Cholangitis (PBC) is an update of the PBC guidelines published in 2009 …

Medullary thymic epithelial cells (mTECs) ectopically express thousands of peripheral-tissue
antigens (PTAs), which drive deletion or phenotypic diversion of self-reactive immature T …

Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …

Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an
autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury …

Enzymatic oxidation of cholesterol generates numerous distinct bile acids that function both
as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that …

Chromatin profiling has emerged as a powerful means of genome annotation and detection
of regulatory activity. The approach is especially well suited to the characterization of non …

Sjögren's syndrome is a common autoimmune disease (affecting∼ 0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we …

Complex disease genetics has been revolutionised in recent years by the advent of genome-
wide association (GWA) studies. The chronic inflammatory bowel diseases (IBDs), Crohn's …