Activation mechanisms and structural dynamics of STIM proteins

M Sallinger, H Grabmayr, C Humer… - The Journal of …, 2024 - Wiley Online Library
The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …

STIM proteins: an ever-expanding family

H Grabmayr, C Romanin, M Fahrner - International Journal of Molecular …, 2020 - mdpi.com
Stromal interaction molecules (STIM) are a distinct class of ubiquitously expressed single-
pass transmembrane proteins in the endoplasmic reticulum (ER) membrane. Together with …

Engineering of NEMO as calcium indicators with large dynamics and high sensitivity

J Li, Z Shang, JH Chen, W Gu, L Yao, X Yang, X Sun… - Nature …, 2023 - nature.com
Genetically encoded calcium indicators (GECIs) are indispensable tools for real-time
monitoring of intracellular calcium signals and cellular activities in living organisms. Current …

Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling

SM Emrich, RE Yoast, P Xin, V Arige, LE Wagner… - Cell reports, 2021 - cell.com
Summary Stromal-interaction molecules (STIM1/2) sense endoplasmic reticulum (ER) Ca 2+
depletion and activate Orai channels. However, the choreography of interactions between …

An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1

Y Zhou, MR Jennette, G Ma, SA Kazzaz… - Nature …, 2023 - nature.com
Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic
reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but …

Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling

G Ma, L He, S Liu, J Xie, Z Huang, J Jing… - Nature …, 2020 - nature.com
Genetically encoded photoswitches have enabled spatial and temporal control of cellular
events to achieve tailored functions in living cells, but their applications to probe the …

Engineering of a bona fide light-operated calcium channel

L He, L Wang, H Zeng, P Tan, G Ma, S Zheng… - Nature …, 2021 - nature.com
The current optogenetic toolkit lacks a robust single-component Ca2+-selective ion channel
tailored for remote control of Ca2+ signaling in mammals. Existing tools are either derived …

Optical control of CRAC channels using photoswitchable azopyrazoles

X Yang, G Ma, S Zheng, X Qin, X Li, L Du… - Journal of the …, 2020 - ACS Publications
The Ca2+ release-activated Ca2+ (CRAC) channels control many Ca2+-modulated
physiological processes in mammals. Hyperactivating CRAC channels are known to cause …

STIM and orai mediated regulation of calcium signaling in age-related diseases

HE Collins, D Zhang, JC Chatham - Frontiers in Aging, 2022 - frontiersin.org
Tight spatiotemporal regulation of intracellular Ca2+ plays a critical role in regulating diverse
cellular functions including cell survival, metabolism, and transcription. As a result …

Celastrol inhibits store operated calcium entry and suppresses psoriasis

X Yuan, B Tang, Y Chen, L Zhou, J Deng… - Frontiers in …, 2023 - frontiersin.org
Introduction: Psoriasis is an inflammatory autoimmune skin disease that is hard to cure and
prone to relapse. Currently available global immunosuppressive agents for psoriasis may …