There is an extensive literature relating to factors associated with the development of
Alzheimer's disease (AD), but less is known about factors which may contribute to its …

Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid
(CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a critical role in …

Ever since the discovery of APOE 4 around 25 years ago, researchers have been excited
about the potential of a blood test for Alzheimer's disease (AD). Since then researchers have …

Cerebrospinal fluid (CSF) biomarkers have been extensively investigated in the Alzheimer's
disease (AD) field, and are now being applied in clinical practice. CSF amyloid-beta (A1 …

Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that is
most prevalent in elderly individuals, especially in developed countries, and its prevalence …

Evidence suggests the ɛ4 allele of the apolipoprotein E (APOE) gene may accelerate an
age-related process of cortical thickening and cerebral blood flow (CBF) reduction in the …

Background: Whether the epidemiological association of amyloid-ß (Aß) and tau pathology
in late-onset Alzheimer's disease (LOAD) is causal remains unclear. Objective: We aimed to …

Alzheimer's disease (AD) is the most common cause of dementia, and its frequency is
increasing fast due to prolonged lifespan. Among the growing number of genetic risk factors …

This doctoral thesis was supported by a scholarship from the Generalitat Valencia
(ACIF/2019/062), under the Fondo Social Europeo 2014-2020 program. The three months …

Understanding the biology of the disease may help in the development of new therapeutic
strategies and biomarkers. The authors were successful in decoding the associations …